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Genes Dev. 2004 Oct 1;18(19):2336-41. Epub 2004 Sep 15.

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.

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1
Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.

PMID:
15371326
PMCID:
PMC522982
DOI:
10.1101/gad.1239604
[Indexed for MEDLINE]
Free PMC Article
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