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Int Rev Immunol. 2004 Sep-Dec;23(5-6):383-411.

Molecular makeup of HIV-1 envelope protein.

Author information

1
Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Belgrade, Yugoslavia. veljko01@hotmail.com

Abstract

A broad range of structural, functional, and immunological similarities between HIV-1 gp120 and human proteins, especially those participating in immune responses, highlight gp120 as a pleiotropic protein that can in different ways affect many important functions of the human immune system. Here we described some of these properties of HIV-1 gp120 that represent the main obstacle in the development of effective and safe AIDS vaccine.

PMID:
15370272
DOI:
10.1080/08830180490432749
[Indexed for MEDLINE]

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