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Cell. 2004 Sep 17;118(6):671-4.

At the crossroads of inflammation and cancer.

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  • 1Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands. clevers@niob.knaw.nl

Abstract

Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis. Cyclooxygenases are key to both diseases, yet the molecular basis of the association remains incompletely understood. Two recent Cell (Greten et al., 2004; Rakoff-Nahoum et al., 2004) papers illuminate roles of Toll-like receptors and the NF-kappaB pathway in the control of epithelial homeostasis in health and disease.

PMID:
15369667
DOI:
10.1016/j.cell.2004.09.005
[PubMed - indexed for MEDLINE]
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