Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Biochem. 2004 Oct 1;93(2):224-32.

Bone morphogenetic proteins in vertebrate hematopoietic development.

Author information

1
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

Abstract

During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precisely controlled. Bone morphogenic proteins (BMPs) have been implicated in hematopoietic development in the vertebrate embryo and stimulate the proliferation and/or differentiation of human cord blood hematopoietic stem cells (HSC) and embryonic stem cells in vitro. Here we review the mechanisms of action and potential roles of these soluble signaling molecules in vertebrate hematopoiesis.

PMID:
15368350
DOI:
10.1002/jcb.20191
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center