Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2004 Aug;5(8):658-66.

Cytoskeletal regulation: rich in lipids.

Author information

1
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, Pennsylvania 19104, USA. janmey@mail.med.upenn.edu

Abstract

Phosphorylated derivatives of the phospholipid phosphatidylinositol, or phosphoinositides, are implicated in many aspects of cell function. Binding of phosphoinositides that are localized within cell membranes to soluble protein ligands allows spatially selective regulation at the cytoplasm-membrane interface. Recently, studies that relate phosphoinositide production to membrane domains are converging with those that show effects of these lipids on the assembly of cellular actin, and are therefore linking membrane and cytoskeletal structures in new ways.

PMID:
15366709
DOI:
10.1038/nrm1434
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center