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Nat Rev Mol Cell Biol. 2004 Aug;5(8):635-46.

The co-workers of actin filaments: from cell structures to signals.

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1
UMR144 Centre National de la Recherche Scientifique/Institut Curie, Paris, France.

Abstract

Cells have various surface architectures, which allow them to carry out different specialized functions. Actin microfilaments that are associated with the plasma membrane are important for generating these cell-surface specializations, and also provide the driving force for remodelling cell morphology and triggering new cell behaviour when the environment is modified. This phenomenon is achieved through a tight coupling between cell structure and signal transduction, a process that is modulated by the regulation of actin-binding proteins.

PMID:
15366707
DOI:
10.1038/nrm1437
[Indexed for MEDLINE]
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