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Arch Neurol. 2004 Sep;61(9):1386-9.

Neurologic impairment 10 years after optic neuritis.

Author information

1
Jaeb Center for Health Research, 15310 Amberly Drive, Tampa, FL 33647, USA.

Abstract

BACKGROUND:

Participants enrolled in the Optic Neuritis Treatment Trial have been observed for more than a decade to assess the relationship between optic neuritis and the development of clinically definite multiple sclerosis.

OBJECTIVE:

To assess neurologic disability 10 to 12 years after an initial episode of optic neuritis.

DESIGN:

Longitudinal follow-up of a clinical trial.

SETTING:

Fourteen Optic Neuritis Treatment Trial clinical centers performed standardized neurologic examinations, including an assessment of neurologic disability.

PARTICIPANTS:

One hundred twenty-seven patients who had developed clinically definite multiple sclerosis.

MAIN OUTCOME MEASURES:

Functional Systems Scale and Expanded Disability Status Scale.

RESULTS:

The disability of most patients was mild, with 65% of patients having an Expanded Disability Status Scale score lower than 3.0. The degree of disability appeared to be unrelated to whether the baseline magnetic resonance imaging scan was lesion-free or showed lesions (P =.51). Among patients with baseline lesions, the degree of disability was unrelated to the number of lesions that were present on the scan (P =.14). Two patients died owing to severe multiple sclerosis, one of whom had no lesions revealed on the baseline scan.

CONCLUSION:

Most patients who develop clinically definite multiple sclerosis following an initial episode of optic neuritis will have a relatively benign course for at least 10 years.

PMID:
15364684
DOI:
10.1001/archneur.61.9.1386
[Indexed for MEDLINE]

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