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Trends Genet. 2004 Oct;20(10):464-7.

Retrotransposition of Alu elements: how many sources?

Author information

1
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, Baton Rouge, LA 70803, USA.

Abstract

It is generally thought that only a few Alu elements are capable of retrotransposition and that these 'master' sources produce inactive copies. Here, we use a network phylogenetic approach to demonstrate that recently integrated human-specific Alu subfamilies typically contain 10-20% of secondary source elements that contributed 20-40% of all subfamily members. This multiplicity of source elements provides new insight into the remarkably successful amplification strategy of the Alu family.

PMID:
15363897
DOI:
10.1016/j.tig.2004.07.012
[Indexed for MEDLINE]

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