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Curr Opin Cell Biol. 2004 Oct;16(5):565-71.

Integrin-linked kinase: integrin's mysterious partner.

Author information

  • 1Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

Abstract

Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.

PMID:
15363808
DOI:
10.1016/j.ceb.2004.07.004
[PubMed - indexed for MEDLINE]
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