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Dev Cell. 2004 Sep;7(3):291-9.

Gene-regulatory interactions in neural crest evolution and development.

Author information

1
California Institute of Technology, 1200 East California Boulevard, Pasadena 91125, USA.
2
CA Inst Technol, Pasadena

Abstract

In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus. While the early stages of ectodermal patterning appear conserved between amphioxus and vertebrates, later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. This difference may reflect co-option of genetic pathways which conferred novel properties upon the evolving vertebrate neural plate border, potentiating the evolution of definitive neural crest.

PMID:
15363405
DOI:
10.1016/j.devcel.2004.08.007
[Indexed for MEDLINE]
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