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Stud Health Technol Inform. 2004;107(Pt 1):336-40.

Evolution of a Foundational Model of Physiology: symbolic representation for functional bioinformatics.

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  • 1Structural Informatics Group, University of Washington, Seattle, WA, USA.


We describe the need for a Foundational Model of Physiology (FMP) as a reference ontology for "functional bioinformatics". The FMP is intended to support symbolic lookup, logical inference and mathematical analysis by integrating descriptive, qualitative and quantitative functional knowledge. The FMP will serve as a symbolic representation of biological functions initially pertaining to human physiology and ultimately extensible to other species. We describe the evolving architecture of the FMP, which is based on the ontological principles of the BioD biological description language and the Foundational Model of Anatomy (FMA).

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