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Vision Res. 2004;44(22):2551-7.

The effect of disrupting the human magnocellular pathway on global motion perception.

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Department of Ophthalmology and Visual Sciences, University of British Columbia, 4480 Oak Street, Room A146, Vancouver, BC, Canada V6H 3V4.


The purpose of this study was to demonstrate the effect of human magnocellular (M)-pathway disruption on global motion perception. Coherence thresholds for global motion direction discrimination in random dot patterns were determined at slow and moderate dot speeds: (1) after adaptation to full-field sinusoidal flicker or a steady gray field, and (2) on a red or a gray background. Adaptation to flicker and a red background increased motion coherence thresholds relative to the gray baseline conditions at both dot speeds. Physiological studies have shown that M cells in the retina and LGN are inhibited by red light and are a main contributor to flicker perception in monkeys. Therefore, our results suggest that interference with processing in the subcortical M pathway disrupts higher-level motion integration.

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