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Biochimie. 2004 Jun;86(6):419-23.

DNA interstrand cross-linking by a mycotoxic diepoxide.

Author information

1
Department of Chemistry, Colby College, 5757 Mayflower Hill Drive, Maine Waterville, ME 04901, USA. jtmillar@colby.edu

Abstract

The diepoxide mycotoxin (2R, 3R, 8R, 9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol (repandiol) was both isolated from the mushroom Hydnum repandum and synthesized de novo. Repandiol was found to form interstrand cross-links within a restriction fragment of DNA, linking deoxyguanosines on opposite strands primarily within the 5'-GNC and 5'-GNNC sequences preferred by diepoxyoctane. However, repandiol was a significantly less efficient cross-linker than either of the diepoxyalkanes (diepoxyoctane and diepoxybutane) to which it was compared.

PMID:
15358058
DOI:
10.1016/j.biochi.2004.03.010
[Indexed for MEDLINE]
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