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Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73.

Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.

Author information

1
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0540, USA.

Abstract

A graphics model of the human 5-HT6 receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6 antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. Furthermore, the model explains many of the empirical results from our previous structure-affinity studies.

PMID:
15357994
DOI:
10.1016/j.bmcl.2004.05.076
[Indexed for MEDLINE]

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