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Bioorg Med Chem Lett. 2004 Sep 6;14(17):4557-62.

Discovery of new chemical leads for prostaglandin D2 receptor antagonists.

Author information

1
Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan. torisu@ono.co.jp

Abstract

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.

PMID:
15357992
DOI:
10.1016/j.bmcl.2004.06.006
[Indexed for MEDLINE]

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