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Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6.

Anti-HIV activity of some synthetic lignanolides and intermediates.

Author information

1
Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Avda. Menéndez Pidal s/n 14004, Spain.

Abstract

The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by either, the HIV-1 Tat protein or the cellular transcription factor NF-kappaB, both known as crucial factors in HIV-1 replication. Among the compounds tested, three of them 2, 4 and 13 were further analysed for their anti-HIV-1 activity by recombinant virus assays, showing a suitable profile for development of novel anti-HIV-1 drugs.

PMID:
15357976
DOI:
10.1016/j.bmcl.2004.06.047
[Indexed for MEDLINE]

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