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Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52.

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors.

Author information

1
Department of Medicinal Chemistry, Biovitrum AB, SE-751 37 Uppsala, Sweden.

Abstract

The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.

PMID:
15357970
DOI:
10.1016/j.bmcl.2004.06.058
[Indexed for MEDLINE]

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