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Immunity. 2004 Sep;21(3):391-400.

Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state.

Author information

1
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 312 Church Street SE, Minneapolis 55455, USA.

Abstract

TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antigen-presenting cell that initiated this response was the epidermal Langerhans cell. Naive CD8 T cells proliferated extensively, migrated to tissues, developed effector function, and were capable of making a recall response. These features are very different from the abortive activation of CD8 T cells that occurred in response to the same antigen presented by APC from other tissues. Furthermore, tolerance was dominant when the antigen was presented by both Langerhans cells and other APC. These data suggest that Langerhans cells do not have tolerogenic properties in the steady state.

PMID:
15357950
DOI:
10.1016/j.immuni.2004.07.019
[Indexed for MEDLINE]
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