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Clin Infect Dis. 2004 Sep 1;39(5):732-5. Epub 2004 Aug 16.

The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study.

Author information

1
Div. of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA. jlo@itsa.ucsf.edu

Abstract

Pharmacologic doses of growth hormone (GH) reduce HIV-associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity. Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.

PMID:
15356790
PMCID:
PMC3170406
DOI:
10.1086/422725
[Indexed for MEDLINE]
Free PMC Article

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