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Allergy. 2004 Oct;59(10):1063-7.

The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults.

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1
Department of Public Health Sciences, Kings College London (Guys' Campus), London, UK.

Abstract

BACKGROUND:

A negative association of oro-faecally spread infection with serological markers of sensitization and allergic disease has been reported.

METHOD:

Previous infection with hepatitis A and Helicobacter pylori was assessed in a community-based sample of young British adults and associations with serum-specific IgE to environmental allergens, asthma-like symptoms and hay fever were examined.

RESULTS:

There was no association of previous infection with hepatitis A or H. pylori with wheeze or hay fever. There was no evidence of an association of infection with either agent and sensitization except for the isolated finding of a lower prevalence of sensitization to grass in those with IgG antibodies to H. pylori (OR 0.65, 95% CI 0.43-0.99). This association did not explain the negative association of family size with sensitization to grass.

CONCLUSION:

In this population, there was no evidence that infection with hepatitis A or H. pylori was associated with lower levels of IgE sensitization, asthma or hay fever except for an isolated finding of a negative association of H. pylori infection with sensitization to grass.

[Indexed for MEDLINE]

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