Format

Send to

Choose Destination
See comment in PubMed Commons below
J Exp Med. 2004 Sep 6;200(5):551-8.

The PYRIN connection: novel players in innate immunity and inflammation.

Author information

1
Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, 1814 MBRCC, Morgantown, WV 26506-9300, USA. cstehlik@hsc.wvu.edu

Abstract

Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.

PMID:
15353551
PMCID:
PMC2212741
DOI:
10.1084/jem.20032234
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center