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Fitoterapia. 2004 Sep;75(6):539-51.

Chronic toxicity of Gynostemma pentaphyllum.

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Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, 88/7 Tiwanont road, Muang, Nonthaburi 11000, Thailand.


The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment.

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