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Ophthalmology. 2004 Sep;111(9):1658-62.

Mechanism of ocular hypotensive action of bimatoprost (Lumigan) in patients with ocular hypertension or glaucoma.

Author information

1
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

PURPOSE:

To determine the mechanism of ocular hypotensive action of bimatoprost in patients with ocular hypertension or glaucoma.

DESIGN:

Double-masked, placebo-controlled, randomized, paired comparison crossover study of the effect of bimatoprost on aqueous humor dynamics.

PARTICIPANTS AND CONTROLS:

Twenty-nine patients with ocular hypertension or glaucoma.

METHODS:

Bimatoprost and a placebo were administered once a day, in the evening, for 7 days before assessment of aqueous dynamics using tonometry, Schiƶtz tonography, and fluorophotometry. Intraocular pressure (IOP) response to water drinking was measured.

MAIN OUTCOME MEASURES:

Aqueous humor flow rate, outflow facility, and IOP.

RESULTS:

Intraocular pressure was lowered 29% in the morning and 33% at noon by bimatoprost. Aqueous humor flow was unchanged. Tonographic facility of outflow was increased 47% by bimatoprost relative to the placebo. Assuming an extraocular pressure of 8 mmHg and that extraocular pressure is not altered by bimatoprost, the calculated rate of pressure-insensitive outflow was increased 95% by bimatoprost. During the first hour after water drinking, bimatoprost dampened the IOP rise.

CONCLUSION:

As was seen in healthy normal eyes, bimatoprost increased both the pressure-sensitive and the pressure-insensitive outflows of aqueous humor in patients with ocular hypertension or glaucoma. Bimatoprost had no significant effect on aqueous humor formation.

Comment in

PMID:
15350319
DOI:
10.1016/j.ophtha.2004.02.006
[Indexed for MEDLINE]

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