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Mol Cell. 2004 Sep 10;15(5):661-75.

Regulation of protein kinases; controlling activity through activation segment conformation.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92116, USA.

Abstract

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity.

PMID:
15350212
DOI:
10.1016/j.molcel.2004.08.024
[Indexed for MEDLINE]
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