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Immunity. 2004 Jul;21(1):1-2.

Mysterious origin of plasmacytoid dendritic cell precursors.

Author information

1
Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.

Abstract

The origin of plasmacytoid dendritic cell precursors (pDC) has been controversial. This manuscript shows that CLP and CMP both can give rise to pDCs. pDCs derived from CMP express RAG gene products and show IgHD-J rearrangement, suggesting that pDC represent a unique lineage whose gene expression program shows substantial plasticity.

PMID:
15345213
DOI:
10.1016/j.immuni.2004.07.003
[Indexed for MEDLINE]
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