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Genome Biol. 2004;5(9):240. Epub 2004 Aug 27.

Chemical genomics in yeast.

Author information

1
Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA. charles.brenner@dartmouth.edu

Abstract

Many drugs have unknown, controversial or multiple mechanisms of action. Four recent 'chemical genomic' studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathway-drug interactions.

PMID:
15345040
PMCID:
PMC522863
DOI:
10.1186/gb-2004-5-9-240
[Indexed for MEDLINE]
Free PMC Article

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