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J Clin Invest. 2004 Sep;114(5):605-10.

Dangerous liaisons at the virological synapse.

Author information

  • 1Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland. vincent.piguet@medecine.unige.ch

Abstract

Cell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread.

PMID:
15343375
PMCID:
PMC514595
DOI:
10.1172/JCI22812
[PubMed - indexed for MEDLINE]
Free PMC Article
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