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Nat Rev Cancer. 2004 Sep;4(9):718-27. doi: 10.1038/nrc1434.

Switching on kinases: oncogenic activation of BRAF and the PDGFR family.

Author information

1
Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London W12 ONN, UK. n.dibb@imperial.ac.uk

Abstract

The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided important insights into why these very different kinases share similar oncogenic hot spots and why the PDGFR juxtamembrane region is also a frequent oncogenic target. This research has implications for other kinases that are mutated in human tumours and for the treatment of cancer using kinase inhibitors.

PMID:
15343278
DOI:
10.1038/nrc1434
[Indexed for MEDLINE]

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