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Nat Rev Cancer. 2004 Sep;4(9):707-17.

Gene-promoter hypermethylation as a biomarker in lung cancer.

Author information

1
Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. SBelinsk@lrri.org

Abstract

Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.

PMID:
15343277
DOI:
10.1038/nrc1432
[Indexed for MEDLINE]

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