Send to

Choose Destination
Semin Immunol. 1992 Feb;4(1):35-41.

Functional analysis of human T cell subsets defined by CD45 isoform expression.

Author information

Imperial Cancer Research Fund Human Tumour Immunology Group, University College and Middlesex School of Medicine, London, UK.


The properties of human CD45RA and CD45RO T cells are described. CD45RO cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45RO cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long-lived. The lineage relationship of the two subsets is not clear but in vivo and in vitro evidence suggests bi-directional conversion between CD45RA and CD45RO phenotypes.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center