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J Bacteriol. 2004 Sep;186(18):6316-9.

Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs.

Author information

1
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. pxqliu@dal.ca

Abstract

The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements.

PMID:
15342603
PMCID:
PMC515151
DOI:
10.1128/JB.186.18.6316-6319.2004
[Indexed for MEDLINE]
Free PMC Article
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