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Genetics. 2004 Aug;167(4):2127-31.

A potential regulatory polymorphism upstream of hairy is not associated with bristle number variation in wild-caught Drosophila.

Author information

1
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697-2525, USA. sjm@uci.edu

Abstract

To extend results from laboratory genetic mapping experiments to natural populations it is necessary to estimate the phenotypic effects attributable to laboratory-identified genetic factors in nature. We retested a polymorphism found to be strongly associated with an increase of 0.35 sternopleural bristles in laboratory strains in two large samples of wild-caught Drosophila melanogaster. Despite >90% power to detect effects as low as 0.27 bristles (<1% of the total variation in bristle number) we did not replicate the association in nature. Potential explanations for this result are explored.

PMID:
15342546
PMCID:
PMC1471012
DOI:
10.1534/genetics.104.026732
[Indexed for MEDLINE]
Free PMC Article

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