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Bioorg Med Chem Lett. 2004 Oct 4;14(19):4915-8.

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors.

Author information

1
Athersys, Inc., 3201 Carnegie Ave., Cleveland, OH 44115, USA. ntumey@athersys.com

Abstract

There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. In this report, we describe the identification and SAR of a series of 2,4-diketobutyric acid FEN1 inhibitors.

PMID:
15341951
DOI:
10.1016/j.bmcl.2004.07.028
[Indexed for MEDLINE]

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