Tumor metastasis: a new twist on epithelial-mesenchymal transitions

Curr Biol. 2004 Sep 7;14(17):R719-21. doi: 10.1016/j.cub.2004.08.048.

Abstract

Epithelial-mesenchymal transitions are essential for normal embryonic development and for progression of non-invasive tumor cells into malignant, metastatic carcinomas. Twist, an important regulator of morphogenesis in the embryo, has recently been implicated in the onset of invasive behavior during tumor progression.

Publication types

  • Review

MeSH terms

  • Animals
  • Cadherins / metabolism
  • Cell Adhesion / physiology
  • Cell Line
  • DNA-Binding Proteins / metabolism
  • Epithelium / physiology
  • Gene Expression Regulation, Neoplastic*
  • Mesoderm / physiology
  • Mice
  • Models, Biological*
  • Neoplasm Metastasis / physiopathology*
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / physiology
  • Snail Family Transcription Factors
  • Transcription Factors / metabolism*
  • Transcription Factors / physiology
  • Twist-Related Protein 1

Substances

  • Cadherins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Snail Family Transcription Factors
  • Transcription Factors
  • Twist-Related Protein 1