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MAGMA. 2004 Sep;17(1):47-61. Epub 2004 Aug 31.

High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism.

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1
Centre de Résonance Magnétique, Biologique et Médicale UMR CNRS 6612, Faculté de Médecine, 27 Bd J. Moulin, 13005 Marseille, France. viola@medecine.univ-mrs.fr

Abstract

Cerebral metabolic changes that concur to motor and/or cognitive disorders in actively drinking alcoholics are not well established. We tested the hypothesis that chronic alcoholics exhibit profound alterations in the cerebral metabolism of scyllo-inositol. Brain metabolism was explored in nine actively drinking and 11 recently detoxified chronic alcoholics by in vivo brain (1)H-MRS and in vitro(1)H-MRS of blood serum and cerebrospinal fluid. The cohort was composed of individuals with acute, subacute or chronic encephalopathy or without any clinical encephalopathy. Chronic alcoholism is associated with a hitherto unrecognized accumulation of brain scyllo-inositol. Our results suggest that scyllo-inositol is produced within the central nervous system and shows a diffuse but heterogenous distribution in brain where it can persist several weeks after detoxification. Its highest levels were observed in subjects with a clinically symptomatic alcohol-related encephalopathy. When detected, brain scyllo-inositol takes part in a metabolic encephalopathy since it is associated with reduced N-acetylaspartate and increased creatine. High levels of cerebral scyllo-inositol are correlated with altered glial and neuronal metabolism. Our findings suggest that the accumulation of scyllo-inositol may precede and take part in the development of symptomatic alcoholic metabolic encephalopathy.

PMID:
15340856
DOI:
10.1007/s10334-004-0044-x
[Indexed for MEDLINE]
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