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Acta Neurochir (Wien). 2004 Sep;146(9):1033-8; discussion 1038. Epub 2004 Jun 28.

Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult.

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1
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Abstract

A 22-year-old man presented with a rare case of atypical teratoid/rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.

PMID:
15340816
DOI:
10.1007/s00701-004-0313-5
[Indexed for MEDLINE]
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