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Nat Genet. 2004 Sep;36(9):932-4.

Cancer chromosomes in crisis.

Abstract

The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

PMID:
15340427
DOI:
10.1038/ng0904-932
[Indexed for MEDLINE]

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