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Nat Rev Drug Discov. 2004 Sep;3(9):801-8.

Biochemical mechanisms of drug action: what does it take for success?

Author information

1
Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, California 94304, USA. david.swinney@roche.com

Abstract

Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks.

PMID:
15340390
DOI:
10.1038/nrd1500
[Indexed for MEDLINE]

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