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Nat Rev Mol Cell Biol. 2004 Sep;5(9):752-62.

Apoptosis and genomic instability.

Author information

1
Institute of Environmental Medicine, Karolinska Institutet, Box 210, Nobels väg 13, SE-171 77 Stockholm, Sweden. boris.zhivotovsky@imm.ki.se

Abstract

Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks, experience telomere dysfunction or are in an abnormal polyploid state. Furthermore, DNA-repair proteins can regulate apoptosis. So, genomic instability and apoptosis are intimately linked phenomena, with important implications for the pathophysiology of cancer.

PMID:
15340382
DOI:
10.1038/nrm1443
[Indexed for MEDLINE]

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