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Nat Rev Mol Cell Biol. 2004 Sep;5(9):739-51.

The SCF ubiquitin ligase: insights into a molecular machine.

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1
Department of Pathology and New York University Cancer Institute, New York University Medical Center, 550 First Avenue, MSB 599, New York, New York 10016, USA.

Abstract

Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

PMID:
15340381
DOI:
10.1038/nrm1471
[Indexed for MEDLINE]
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