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Trends Biochem Sci. 1992 Apr;17(4):135-40.

NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats.

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Unité de Biologie Moléculaire du Gène, U. 277 INSERM, Institut Pasteur, Paris, France.


Molecular cloning of the subunits of the transcription factor NF-kappa B and its inhibitor l kappa B revealed regions of sequence homology with two different classes of proteins: the Rel/dorsal family and a heterogeneous group of proteins containing ankyrin-like repeats. Both the Rel/dorsal homology domain and the ankyrin-like repeats appear to play important roles in protein-protein interactions that regulate localization and activity of the NF-kappa B subunits.

[Indexed for MEDLINE]

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