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Cell. 2004 Sep 3;118(5):539-44.

The lingering enigma of the allelic exclusion mechanism.

Author information

1
Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma.

PMID:
15339659
DOI:
10.1016/j.cell.2004.08.023
[Indexed for MEDLINE]
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