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J Am Coll Cardiol. 2004 Sep 1;44(5):1113-23.

Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism.

Author information

1
Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), The Netherlands.

Abstract

OBJECTIVES:

We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion.

BACKGROUND:

The FGFs display cardioprotective effects during ischemia and reperfusion.

METHODS:

We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion.

RESULTS:

Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death.

CONCLUSIONS:

The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK.

PMID:
15337227
DOI:
10.1016/j.jacc.2004.05.067
[Indexed for MEDLINE]
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