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Biochem Biophys Res Commun. 2004 Oct 1;322(4):1326-35.

Ca2+ homeostasis in apoptotic resistance of prostate cancer cells.

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Laboratoire de Physiologie Cellulaire, INSERM EPI-9938, USTL, Bat. SN3, 59655 Villeneuve d'Ascq Cedex, France.


Ca2+ is a universal messenger regulating many physiological functions including such an important one, as the ability of the cell to undergo orderly self-destruction upon completion of its mission, called apoptosis. If this function is compromised unwanted cells may eventually take over the tissue turning it into a cancer. Ca2+ dependency of apoptosis, when its all aspects are learned and understood and key molecular players identified, may provide a good opportunity for controlling tumor growth. In the present mini-review we describe the major molecular determinants of Ca2+ homeostasis in prostate cancer cells and establish their role in the transformation to apoptosis-resistant cell phenotypes typical of advanced androgen-independent prostate cancer. We show that the hallmark of such transformation is the inhibition of apoptosis pathway associated with endoplasmic reticulum Ca2+ store depletion.

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