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Regul Pept. 1992 Mar 5;38(1):1-11.

Signal transduction of V1-vascular vasopressin receptors.

Author information

1
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4982.

Abstract

This review covers the recent developments gained in the exploration of V1-vascular vasopressin (AVP) receptors. We examine the different radioligands available for the pharmacological characterization of these receptors. The immediate transmembrane signaling of V1-vascular AVP receptors involves ligand-receptor complex formation, receptor lateral mobility and internalization, coupling to a Gq protein, activation of phospholipases A2, C and D, translocation and activation of protein kinase C, production of inositol 1,4,5-triphosphate and 1,2-diacylglycerol, mobilization of intracellular calcium, alteration of intracellular pH with activation of the Na+/H+ exchanger, calmodulin activation and myosin light chain phosphorylation. The secondary nuclear signal mechanisms triggered by activation of V1-vascular AVP receptors includes tyrosine phosphorylation, induction of gene expression and protein synthesis.

PMID:
1533467
DOI:
10.1016/0167-0115(92)90067-5
[Indexed for MEDLINE]

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