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Arthritis Rheum. 2004 Aug 15;51(4):578-85.

Impact of fatigue on health-related quality of life in rheumatoid arthritis.

Author information

1
Academic Medical Center, University of Amsterdam, Amsterdam. i.rupp@amc.uva.nl

Abstract

OBJECTIVE:

To multidimensionally assess fatigue in rheumatoid arthritis (RA) and to evaluate the impact of fatigue on health-related quality of life (HRQOL).

METHODS:

The study was conducted in 1999 among 490 RA patients with varying disease duration. Fatigue was measured with the Multidimensional Fatigue Inventory (MFI-20) and HRQOL with a validated Dutch version of the RAND 36-Item Health Survey. We evaluated the impact of fatigue on HRQOL by multiple linear regression analyses taking into account RA-related pain and depressive symptoms.

RESULTS:

Different aspects of fatigue selectively explained different dimensions of HRQOL. The MFI-20 was entered last to the linear regression models, resulting in an additional increase of explained variance of 1% (mental health) to 14% (vitality).

CONCLUSION:

The multidimensional portrayal of RA-related fatigue can be used to develop intervention strategies targeted to specific aspects of fatigue. Fatigue, supplementary to RA-related pain and depressive symptoms, appears to be a feasible and treatable target in the clinical management of RA to increase HRQOL.

PMID:
15334430
DOI:
10.1002/art.20539
[Indexed for MEDLINE]
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