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Thorax. 2004 Sep;59(9):769-72.

Antitussive activity of iodo-resiniferatoxin in guinea pigs.

Author information

1
Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy. tvm@unife.it

Abstract

BACKGROUND:

Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1).

METHODS:

The ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants (capsaicin and citric acid) was tested in non-anaesthetised guinea pigs.

RESULTS:

Pretreatment with I-RTX either intraperitoneally (0.03-0.3 micromol/kg) or by aerosol (0.1-3 microM) reduced the number of coughs produced by inhalation of citric acid (0.25 M) and capsaicin (30 microM) in a dose dependent manner. Capsazepine (CPZ) also reduced citric acid and capsaicin induced cough, but the activity of I-RTX was 10-100 times more potent than CPZ in all the experimental conditions tested.

CONCLUSIONS:

I-RTX is a novel and potent antitussive drug which inhibits cough mediated by agents possibly acting via TRPV1 activation.

Comment in

PMID:
15333853
PMCID:
PMC1747129
DOI:
10.1136/thx.2003.012930
[Indexed for MEDLINE]
Free PMC Article
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