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Nat Neurosci. 2004 Sep;7(9):1003-9.

Differentiation of mouse embryonic stem cells into a defined neuronal lineage.

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1
Friedrich Miescher Institute, CH-4058 Basel, Switzerland.

Abstract

Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.

PMID:
15332090
DOI:
10.1038/nn1301
[Indexed for MEDLINE]

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