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Rev Neurol (Paris). 2004 Jun;160 Spec No 1:5S232-40.

[Meta-analysis of surgery trials in refractory epilepsy].

[Article in French]

Author information

1
Service de Biostatistique-CHU Lyon, EA 3736, Faculté de Médecine Lyon-Laennec, rue Guillaume-Paradin, 69008 Lyon, France. mcu@upcl.univ-Lyon1.fr.

Abstract

OBJECTIVE:

To examine the evidence for efficacy of surgery in the treatment of intractable epilepsy.

METHOD:

Meta-analysis of randomized clinical trials.

RESULTS:

One randomized clinical trial (n=80) and 3 observational studies are available.

INTERPRETATION:

Compared to medical treatment, the surgery increases the proportion of patients who were free of seizure impairing awareness at 1 year (relative risk: 7.67, IC 95% 2.5 à 23.51)

CONCLUSION:

The available evidence about the clinical efficacy of surgery for patient with intractable epilepsies is limited to an unique open randomized clinical trial, that enrolled patient in a single centre, without concealment of the randomization and with a partially subjective primary endpoint. However, this trial shows a substantial effect corresponding to a 8 fold increase in the number of patient without seizure at 1 year. The informational situation will be better when the results of a currently ongoing trial will be available.

PMID:
15331971
[Indexed for MEDLINE]
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