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Pediatr Clin North Am. 2004 Oct;51(5):1229-55.

Molecular genetic basis of sudden cardiac death.

Author information

1
Department of Pediatrics (Cardiology), Texas Children's Hospital and Baylor College of Medicine, 6621 Fannin Street, FC. 430.09, Houston, TX 77030, USA. jtowbin@bcm.tmc.edu

Abstract

This article outlines the up-to-date understanding of the molecular basis of disorders that cause sudden death. Several arrhythmic disorders that cause sudden death have been well-described at the molecular level, including the long QT syndromes and Brugada syndrome; this article reviews the current scientific knowledge of these diseases. Hypertrophic cardiomyopathy, a myocardial disorder that causes sudden death also has been well-studied. Finally, a disorder in which myocardial abnormalities and rhythm abnormalities coexist, arrhythmogenic right ventricular dysplasia, is described.

PMID:
15331282
DOI:
10.1016/j.pcl.2004.04.012
[Indexed for MEDLINE]

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